The product label for ProHeart 12 cites an alarmingly long list of adverse events of ProHeart 6. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Zoetis knows moxidectin can be harmful to dogs. You may report side effects to the FDA at 1-800-FDA-1088. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Stomach pain. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). This content does not have an English version. This leads to increased permeability, influx of chloride ions, hyperpolarization, and muscle paralysis. 5.1 Cutaneous, Ophthalmological and/or Systemic Adverse Reactions Treatment with Moxidectin Tablets may cause cutaneous, ophthalmological and/or systemic reactions of varying severity (Mazzotti reaction). All rights reserved. Medically reviewed by Drugs.com. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Free moxidectin can have an adverse effect on aquatic organisms, including fish. All drugs may cause side effects. Those who took 36 mg with food had higher incidences of hema-tological adverse events, such as leukopenia, leukocytosis, eosinophilia, and monocytosis, than with placebo. This is not a comprehensive list. (And, in case you missed it … there’s 3 times as much moxidectin in ProHeart 12 as Proheart 6 … so side effects are likely to be greater.) Oral: Administer without regard to meals. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Due to its bitter taste, this drug may cause temporary profuse drooling if ingested. Adverse effects. Moxidectin’s chemical formulation is slightly different to Ivermectin, well known here as a horse and livestock deworming remedy. Note: This is not a comprehensive list of all side effects. • It is used to treat eye and skin disease caused by certain worms (O. volvulus). • Mazzoti reaction: Moxidectin treatment may cause cutaneous, ophthalmological, and/or systemic reactions (Mazzoti reaction) of varying severity, due to allergic and inflammatory host responses to the death of microfilariae. Talk to your doctor if you have questions. Antihistamines and/or aspirin have been used for most mild to moderate reactions. Advertising revenue supports our not-for-profit mission. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. SIDE EFFECTS Side effects have not been reported for dogs using the topical product as directed. Moxidectin, an anthelminthic agent, is active against the microfilariae of O. volvulus, but not effective in killing the adult worms. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. There is a trend toward an increased incidence of these adverse reactions in patients with higher microfilarial burden. Some of the side-effects may be rare but serious. Portions of this document last updated: Oct. 01, 2020. Consult your doctor if you observe any of the following side-effects, especially if they do not go away. How Imidacloprid and Moxidectin is Supplied Advantage Multi® … This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Discard unused tablets. Treatment of severe Mazzoti reactions is not definitive, but includes supportive care (eg, hydration and/or parenteral corticosteroids) to treat postural hypotension. Protect from light. These signs disappear without further treatment. All rights reserved. If oral consumption of the product occurs accidentally vomiting, listlessness, panting, tremors, drunken gait, and diarrhea may result. Diarrhea. Moxidectin Tablets are available as white to pale yellow uncoated oval-shaped tablets, debossed on one side with “AKKA”. Diarrhea. Following intravenous (IV) dosing of a combination solution of sarolaner and moxidectin, the sarolaner volume of distribution (V ss ) was 2.4 L/kg and systemic clearance (CL) was 6.0 mL/kg/hr. Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Social media is buzzing about an Australian study on the possible antiviral effects that ivermectin might have on the COVID-19 virus. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Select one or more newsletters to continue. discharge, excessive tearing. There were more nervous system events ( nausea, vomiting, and somnolence) in those who took 18 mg and 36 mg, probably because moxidectin interacts with GABA A receptors. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. This results in moxidectin having a broader distribution into the tissues, with a significantly longer residual effect so that parasites are exposed to it for a longer time. Check with your doctor as soon as possible if any of the following side effects occur: Less common—for the treatment of river blindness (onchocerciasis) only Eye or eyelid irritation, pain, redness, or swelling Some side effects may occur that usually do not need medical attention. Mayo Clinic does not endorse companies or products. It has recently been made available as a 10 percent moxidectin injection in 20 ml vials. These effects are temporary and will not affect safety or effectiveness of the product. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: • Low sodium like headache, trouble focusing, trouble with memory, confusion, weakness, seizures, or change in balance. Once opened, administer within 24 hours. Drug information provided by: IBM Micromedex. They found moxidectin “ was generally safe and well tolerated ”. side effects or only have minor side effects. Copyright © 2021 IBM Watson Health. There are no contraindications listed in the manufacturer’s labeling. Dogs: scratching, rubbing or licking at the application site; lethargy, decreased appetite, vomiting, excitement, facial … Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online, bloating or swelling of the face, arms, hands, lower legs, or feet, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, pounding, or irregular heartbeat or pulse, sores, ulcers, or white spots on the lips or in the mouth, burning, dry, itching, or watering of the eyes, redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid. These are not all of the side effects that may occur. Drugs may be approved days, weeks, or months before they’re launched, so we encourage you to check back. Residual moxidectin mean (range) at 1× injection sites after 1 year was 16.0% (0.045-37.6%) of the administered mass. Studies 2 and 3: no effects were identified in reproductive indices (females) or semen quality characteristics (males). There are no known significant interactions. Other side effects may include scratching, application site reactions, rubbing, lethargy, hyperactivity, uncoordinated walking, trembling, excessive salivation, increased drinking, and coughing or gagging. • Orthostatic hypotension: Orthostatic hypotension may occur, most commonly on the first 1 to 2 days after treatment. These side-effects are possible, but do not always occur. The clinical manifestations of Mazzotti re… Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. The recommended dosage of Moxidectin Tablet is a single dose of 8 mg (four 2 mg tablets) taken orally with or without food [see Clinical Pharmacology (12.3)]. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. Limitations of use: Moxidectin does not kill adult O. volvulus; follow-up evaluation is advised. This content does not have an Arabic version. So it appears, with a real minimum of information, that a human effective dose would be between 0.15 and 0.6 mg per kg or approximately 0.1 to 0.3 mg per pound. get medical help if any of these side effects or any other side effects bother you or do not go away: Stomach pain. Risk may be increased in patients with higher microfilarial burden. trouble seeing. If you notice any of these side effects or have any concerns about your dog, please contact your veterinarian as soon as possible. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Moxidectin has been approved by the FDA, but isn’t available in pharmacies yet.. These are not all of the side effects that may occur. Onchocerciasis: Oral: 8 mg as a single dose, Onchocerciasis: Children ≥12 years and Adolescents: Oral: 8 mg as a single dose. No withholding time has been established, so this product should not be administered to female sheep producing milk for consumption by humans. feeling of having something in the eye. Safety and efficacy of repeat administration of moxidectin in patients with O. volvulus has not been studied. Side effects increased as the dose was raised, so there is no sense in going crazy and using a higher dose. Moxidectin - General Description: Moxidectin is an injectable parasiticde given at the veterinary clinic to dogs 6 months of age and older to prevent heartworm disease. 3 DOSAGE FORMS AND STRENGTHS . This is the first stud … This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. Eight subjects had dizziness or somnolence/lethargy (one in the placebo group, two who took 9 … Available for Android and iOS devices. At a moxidectin dose of 0.024 mg/kg, the moxidectin mean C max was 13.1 ng/mL with a mean T max of 2.4 hours and an absolute bioavailability of 67%. Cough. Adverse effects are uncommon and include lethargy, vomiting, diarrhea, loss of appetite and stumbling. Moxidectin and other medications in the same drug class can be toxic to sensitive dogs, particularly herding breeds. 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